- RESEARCH PROJECT
Human Immunodeficiency Virus (HIV)-infected individuals on antiretroviral
therapy, the persistence of the virus in latently infected cells is thought to
be the barrier for cure of infection. The main latent reservoir is constituted
of resting memory CD4+ T lymphocytes containing integrated proviruses that are
transcriptionally silent. The project is based on our recent progress on the
role of a novel complex containing LEDGF/p75, Iws1 and Spt6 that participates
to post-integration silencing of HIV-1.
project will study the molecular mechanisms involved in the transcriptional
control of HIV latency.
for this position should have strong knowledge and expertise in protein
biochemistry, molecular biology and in the field of transcription. Main
activities: recombinant protein purification, protein complex charaterization,
transcription assays, ChIP assays.